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Regarded as the birthplace of agriculture, the Fertile Crescent was the region located in the Near East, watered by the Tigris and Euphrates rivers, which included what is today the country of Iraq. Traditionally associated (in Jewish, Christian and Muslim faiths) with the earthly location of the Garden of Eden, the Fertile Crescent region boasted unusually fertile soil and produced healthy harvests which furthered early (especially Christian) belief in the area as 'blessed by God’ and present day Muslim conviction of the same.

As crucial as rivers and marshlands were to the rise of civilization in the Fertile Crescent, they were not the only factor in the area's precocity. The area is important as the "bridge" between Africa and Eurasia. This "bridging role" has allowed the Fertile Crescent to retain a greater amount of biodiversity than either Europe or North Africa, where climate changes during the Ice Age led to repeated extinction events due to ecosystems becoming squeezed against the waters of the Mediterranean Sea. Coupled with the Saharan pump theory, this Middle Eastern land-bridge is of extreme importance to the modern distribution of Old World flora and fauna, including the spread of humanity.

The fact that this area has borne the brunt of the tectonic divergence between the African and Arabian plates, and the converging Arabian and Eurasian plates, has also made this region a very diverse zone of high snow-covered mountains, fertile broad alluvial basins and desert plateau, which has also increased its biodiversity further and enabled the survival into historic times of species not found elsewhere.

The region's dramatic variety of elevation gave rise to many species of edible plants for early experiments in cultivation. Most importantly, the Fertile Crescent possessed the wild progenitors of the eight Neolithic founder crops important in early agriculture (i.e. wild progenitors to emmer wheat, einkorn, barley, flax, chick pea, pea, lentil, bitter vetch), and four of the five most important species of domesticated animals—cows, goats, sheep, and pigs—and the fifth species, the horse, lived nearby. Since the Bronze Age, the region's natural fertility has been greatly extended by irrigation works, upon which much of its agricultural production continues to depend.

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